Health insurance services in Korea
are national and compulsory by law, and the data related to medical information
for the entire Korean population are recorded in a national health information
database. A sample cohort database is constructed by stratified random sampling
from this national health information for research purposes. It maintains a
cohort structure continued from a sample in 2002 (Lee, Lee, Park, Shin and Kim,
2016). Based on this recently published medical big data, several medical
studies have been conducted (Kwon, Lim and Park, 2017; Kim, Kwon, Yu, Kim,
Choi, Baik, Park and Kim, 2017; Kim, Lee, Kim, Kim, Choi, Baik, Choi,
Pop-Busui, Park and Kim, 2015; Ko, Yoon, Kim, Kim, Kim and Seo, 2016; Ko, Jo,
Park, Kim, Kim and Park, 2016; Rim, Kim, Han and Chung, 2015).
We apply imputation methods to this
sample cohort data, in particular, to missing values of self-reported
variables. In health screening records, there are variables measured by
health-care professionals, such as height, weight, blood pressure, and blood
sugar. They are reliable and completely observed. On the other hand, some
health screening variables such as smoking period, exercise frequency, and
drinking habits are self-reported. They are likely to be incomplete and inaccurate
as discussed by Crossley and Kennedy (2002), Cambois, Robine and Mormiche
(2007), and Kwon and Park (2016).
Using health screening data of the
sample cohort data for 2011 and 2013, we impute the missing values of smoking
periods (in years) of current smokers in 2013 whose ages were between 20 and 84
and who had health screening records both in 2011 and 2013. Let
be the self-reported smoking period
and
be the minimum value of age
categorized in 5-year classes for person
in year
respectively.
There is no missing data in
as we limited our analysis to those
who answered that they were current smokers in 2013. Unreasonable values of
smoking periods in
are treated as missing, by
comparing smoking periods and ages in 2011 and 2013; i.e. if
meets any of the conditions
or
where
is a minimum age started smoking,
and
and
are tolerances according to human
memory. We denote by
the new smoking period in 2013 to distinguish
it from
with no missing values.
As Raghunathan et al. (2001)
did, we set the upper bound,
to be
minimum age started smoking. Although Raghunathan et al. (2001)
defined the minimum smoking age to be 18 years old, we take the minimum age to
be 10 which is the lowest smoking age observed in the sample cohort data. We
set
for a lower boundary
When
is missing which is 0.09% of data,
we set
to 0. If
is the same as
then we set the
to
to ensure that no denominator of
the proportioned residual given in equation (2.3) is zero.
By adjusting
and
which show the extent to which we
allow the error due to human memory, the missing rate ranges from 44.0% to
73.5%. By taking
when we may allow up to two years
of human memory error, the rate of missing data is 44.0%. When we do not allow
any error at all, that is, letting
for those who smoked in 2013 and
did not smoke in 2011 and letting
for those who smoked both in 2013
and 2011, the rate of missing data is 73.5%.
In order to fit the regression model
for smoking periods, we use sex, age and income level as siginificant
predictors, Table 4.1 shows the summary of data we use in this paper.
Individual income information used to estimate health insurance premiums was observed
in the form of a categorized ordered variable with 11 levels. We re-categorized
the income groups into 3 groups: high (top 30%), low (bottom 30%), and medium
(others) as this improved the fit.
Table 4.1
Summary of data Table summary
This table displays the results of Summary of data missing rate (%), n, mean age, male ratio (%) and income group ratio (%), calculated using (équation) units of measure (appearing as column headers).
missing rate (%)
n
mean age
male ratio (%)
income group ratio (%)
top 30%
bottom 30%
with 2 years tolerance
obs. missing
44.0
19 601
42.6
95.8
47.6
10.4
15 414
48.5
95.2
44.3
15.6
without tolerance
obs. missing
73.5
9 266
38.7
95.9
49.1
7.6
25 749
47.6
95.4
45.1
14.5
This is an empty cell
total
This is an empty cell
35 015
45.2
95.6
46.1
12.7
with
2 years tolerance
0.79
0.99
without tolerance
0.71
0.99
The average age of people who did not
respond to the smoking period question 2013 is about 6 to 9 years older than
that of respondents. The distribution and average of the income indicate that
the nonrespondent’s income level is lower than the respondent’s income level.
Since age and income level are important predictors for smoking period, it is
hard to assume that missing mechanism of the smoking period is MCAR.
As seen in Table 4.1, the
correlation between
and
is as high as 0.99 because of
treating
as a missing value when not
satisfying the logical constraints under the assumption that
is correct. However,
of course has the same problem as
and it is not reliable either.
Despite such a very high correlation, this is the reason for not including
as a predictor. Erroneous boundary
information only affects the individual imputed values, but erroneous boundary
information as a predictor affects the overall regression model estimates,
which greatly affects the overall reliability of imputation. Hence, we only use
the measured variables such as sex, age, and income which are collected by the
government as a basis for the collection of national medical insurance
premiums. Note that the age variable is also used as upper boundary
information.
Since it is highly possible that the
self-reported smoking periods in 2011 are not correct, there should be a
criticism for setting
to be a lower bound. Thus, we
consider another lower bound with
which is the observed smallest
smoking period of current smokers.
4.2 Results
The regression model for the smoking
period in 2013,
is fitted with fully observed cases
as given by Table 4.2.
In Table 4.2, sex(female) is a dummy variable with value 1 indicating female,
age is the central value of age categorized in 5-year classes, and income(low)
and income(mid) are both dummy variables with value 1 indicating membership to
the particular income group.
Table 4.2
Regression model for the smoking period in 2013 Table summary
This table displays the results of Regression model for the smoking period in 2013 with 2 year tolerance and without
tolerance (appearing as column headers).
with 2 year tolerance
without
tolerance
estimate
t-value
estimate
t-value
intercept
-9.42
-54.00
-6.70
-23.97
sex(female)
-8.38
-40.51
-8.58
-28.41
age
0.69
182.34
0.64
96.56
income(low)
-0.32
-2.25
-0.76
-3.21
income(mid)
-0.50
-5.77
-0.99
-7.81
R square
0.66
0.55
Table 4.3 shows the mean of
estimated by each of five
imputation methods with
and
A possible donor size
is allowed to be smaller than 6
when there is not enough sample to compose a donor, but there is no such case
in our data. We consider four different scenarios made up of two settings of
lower boundaries and two tolerances of human memory errors.
Different from the simulation
results, T-NORM under-estimates more seriously than OBS when
The distribution of observed
smoking periods is slightly skewed to the right as the distance between Q50 and
Q95 is farther than that between Q50 and Q5. However, T-NORM imputes a
predictive mean plus a random residual generated from a truncated normal
distribution not from the empirical distribution of residuals which is
right-skewed. Since the lower bound,
is far from the mean, the
possibility of selecting a negative error is higher from the truncated normal
than from the right skewed empirical distribution of residuals. This leads to
the underestimation of T-NORM. All other imputation methods estimate the mean
smoking period higher than OBS as they use empirical residuals.
OBS produces higher mean of smoking
periods with tolerance than without tolerance as the regression coefficient of
age is higher with tolerance than without tolerance as shown in Table 4.2.
Except with T-NORM, the estimated smoking periods are longer without tolerance
than with tolerance, and the gap is smaller when
than
The DBM-PRD method is the most robust
regardless of how we define missing values and the lower boundary. This is a
desirable property of imputation when the boundary information is unreliable.
On the other hands, the estimation results of the existing imputation methods
(i.e., T-NORM, T-MV, T-LRD, T-PMM) clearly depend on the choice of boundary and
human memory tolerance. The estimated distributions of smoking period by the
existing methods move substantially to the right when
relative to when
since
is a more informative boundary than
the constant boundary. However, the distribution with DBM-PRD is only
marginally changed for different boundaries.
Table 4.3
Estimated mean, 5, 25, 50, 75 and 95% quantiles of smoking years of Korean current smokers in 2013 Table summary
This table displays the results of Estimated mean With 2 years tolerance due to human memory (missing rate = 44.0%) and
and
(appearing as column headers).
with
2 years tolerance due to human memory (missing rate = 44.0%)
mean
Q5
Q25
Q50
Q75
Q95
mean
Q5
Q25
Q50
Q75
Q95
OBS
19.55
7.00
12.00
20.00
25.00
40.00
19.55
7.00
12.00
20.00
25.00
40.00
T-NORM
21.46
8.00
14.00
20.00
27.98
40.22
17.66
3.92
10.00
16.99
22.91
35.00
T-MV
22.79
9.00
15.00
20.05
30.00
41.80
21.45
7.01
14.45
20.00
28.17
40.00
T-LRD
22.63
9.00
15.00
20.00
30.00
40.20
21.32
7.00
14.00
20.00
30.00
40.00
T-PMM
22.64
9.00
15.00
20.00
30.00
40.53
21.31
7.00
14.00
20.00
30.00
40.00
DBM-PRD
20.61
6.31
13.00
20.00
26.90
40.00
21.33
7.00
14.00
20.00
30.00
40.00
without any tolerance due to human memory (missing rate = 73.5%)
mean
Q5
Q25
Q50
Q75
Q95
mean
Q5
Q25
Q50
Q75
Q95
OBS
17.25
5.00
11.00
16.00
22.00
32.00
17.25
5.00
11.00
16.00
22.00
32.00
T-NORM
21.92
8.00
14.77
20.66
28.00
40.75
14.61
2.70
8.13
13.64
20.00
30.00
T-MV
24.01
10.00
16.75
22.85
30.34
42.67
21.63
7.19
15.00
20.95
27.68
37.87
T-LRD
24.40
10.00
16.00
23.00
30.00
47.40
21.44
5.00
13.00
20.00
28.80
42.00
T-PMM
24.41
10.00
16.00
23.00
30.00
47.45
21.47
5.00
13.00
20.00
28.80
42.00
DBM-PRD
21.11
7.00
13.00
20.00
27.00
41.80
21.42
5.00
13.00
20.00
28.80
42.00
Figure 4.1 presents the kernel
density estimates of smoking periods using OBS and DBM-PRD under two lower
boundary settings and two tolerances of human memory errors. Imputation by
DBM-PRD moves the distribution of smoking period to the right and spreads it
widely, compared to the distribution constructed only by observations (OBS).
Description for Figure 4.1
Figure made of two graphs
illustrating the kernel density estimates of smoking periods using OBS and
DBM-PRD under two lower boundary settings and two tolerances of human memory
errors. The density is on the y-axis, ranging from 0.0 to 0.6. The smoking
period in years is on the x-axis, ranging from 0 to 60. The first graph is with
a 2 year tolerance and 44.0% of missing values. The second graph is without
tolerance and with 73.5% of missing values. For both graphs, the imputation by
DBM-PRD moves the distribution of smoking period to the right and spreads it
widely, compared to the distribution constructed only by observations (OBS).
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