Table 3
Association between mothers’ postoperative opioid prescription and opioid-related events in their children aged 1 to 24 years within one year of surgery
Model | Number with outcome events | Population | Odds ratio | P-value | ||
---|---|---|---|---|---|---|
Estimate | 95% confidence interval | |||||
From | To | |||||
Crude/unadjusted | 36 | 283,550 | 2.72 | 1.19 | 6.21 | 0.02 |
AdjustedTable 3 Note ‡ | 36 | 281,157 | 2.42 | 1.05 | 5.54 | 0.04 |
Sensitivity analyses | ||||||
Restricting to one randomly selected child per mother | .. | 170,156 | 2.63 | 0.98 | 7.05 | 0.05 |
Restricting to children aged 12 to 24 years | 119,856 | 2.12 | 0.92 | 4.87 | 0.08 | |
Restricting to children of mothers whose surgery was not a caesarean section | .. | 225,426 | 2.07 | 0.91 | 4.75 | 0.08 |
Including children and children of mothers who died within one year of surgery and opioid-related deaths in the outcome | .. | 283,889 | 2.72 | 1.19 | 6.21 | 0.02 |
Sources: 1. Inpatient admissions (Discharge Abstract Database), 2. Same-day surgical procedures (Same Day Surgery Database), 3. Opioid prescriptions (Narcotics Monitoring System), 4. Emergency department presentations (National Ambulatory Care Reporting System), 5. Deaths (Office of the Registrar General – Deaths) and individual-level demographic information (Registered Persons Database), 6. Mother–baby linked database (ICES-derived MOMBABY database). |
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