Table 3
Univariate sensitivity analysis: Cost per quality-adjusted life-year (QALY) compared with No Screening, by screening strategy and screening variables (discount = 5%)
| Screening strategy | Base case | Utility values 25% |
Utility values -25% |
Specificity 100% | Sensitivity 100% | 50% missed screenings | Disutility excluded | Screening cost = $100 | No treatment (drug, surgery, radiation) | No subsequent screening | 75% receive adjuvant chemotherapy | Discount rate = 0% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No Screening | - | Note ...: not applicable | Note ...: not applicable | Note ...: not applicable | Note ...: not applicable | Note ...: not applicable | Note ...: not applicable | Note ...: not applicable | Note ...: not applicable | Note ...: not applicable | Note ...: not applicable | Note ...: not applicable |
| Annual ages 40 to 69 | $150,937 | $120,211 | $201,250 | $125,147 | $128,592 | $131,972 | $190,762 | $116,971 | $4,081,165 | $241,662 | $137,604 | $58,900 |
| Annual ages 40 to 74 | $154,187 | $122,810 | $205,583 | $128,097 | $131,177 | $134,090 | $195,009 | $119,646 | $4,726,306 | $241,662 | $138,757 | $63,233 |
| Annual ages 50 to 69 | $114,778 | $91,076 | $153,037 | $99,421 | $101,858 | $103,318 | $132,970 | $89,701 | $1,240,537 | $93,624 | $103,592 | $52,077 |
| Annual ages 50 to 74 | $120,522 | $95,675 | $160,695 | $105,048 | $107,224 | $108,112 | $140,148 | $94,347 | $1,410,235 | $241,662 | $107,059 | $57,858 |
| Biennial ages 50 to 69 | $95,313 | $75,461 | $127,083 | $80,679 | $83,935 | $94,904 | $107,993 | $76,713 | $1,616,400 | $93,624 | $87,140 | $41,984 |
| Biennial ages 50 to 74 | $100,912 | $79,954 | $134,549 | $86,120 | $89,992 | $99,722 | $114,702 | $81,461 | $1,870,599 | $93,624 | $90,735 | $47,597 |
| Biennial ages 40 to 74 | $126,612 | $100,640 | $168,816 | $103,579 | $107,306 | $120,253 | $154,502 | $100,680 | $5,968,018 | $241,662 | $116,064 | $51,194 |
| Triennial ages 50 to 69 | $94,762 | $74,849 | $126,349 | $78,780 | $85,837 | $95,995 | $107,858 | $77,384 | $1,963,362 | $93,624 | $86,364 | $41,575 |
| Triennial ages 50 to 74 | $99,700 | $78,812 | $132,932 | $83,793 | $91,707 | $100,339 | $113,732 | $81,684 | $2,017,095 | $93,624 | $89,826 | $46,703 |
| Annual ages 40 to 49/ Biennial ages 50 to 69 | $146,333 | $116,540 | $195,111 | $121,352 | $122,534 | $135,003 | $184,737 | $114,221 | $5,834,291 | $241,662 | $135,983 | $53,166 |
| Annual ages 40 to 49/ Biennial ages 50 to 74 | $146,950 | $117,061 | $195,934 | $123,180 | $124,491 | $136,750 | $184,756 | $114,985 | $5,968,397 | $241,662 | $135,473 | $55,855 |
|
... not applicable Source: Canadianized University of Wisconsin Breast Cancer Epidemiology Simulation Model. |
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