Enhancing the OncoSim-Breast model using Canadian breast density information
Articles and reports: 82-003-X202600500002Description: Breast cancer is the most commonly diagnosed cancer among women in Canada. Breast density substantially influences breast cancer risk and mammography performance. However, OncoSim-Breast, a Canadian microsimulation model representing breast cancer control, including cancer onset, screening, and survival, has not previously explicitly accounted for breast density. This study describes the incorporation of density-specific parameters—prevalence, relative risk of breast cancer, and digital mammography performance (sensitivity and specificity)—using data from five Canadian provinces, into the OncoSim-Breast model. Calibration experiments and internal validations were conducted to ensure the updated OncoSim-Breast model aligned with observed data from the Canadian Cancer Registry. Issue Number: 2026005Author(s): Alagoz, Oguzhan; Yaffe, Martin J.; Mainprize, James G.; Simeonov, Dori; Coldman, Andrew; Yong, Jean HE; Garner, Rochelle; Nadeau, ClaudeDOI: https://doi.org/10.25318/82-003-x202600500002-engMain Product:Health Reports
