Flexible models for analyzing longitudinal data in population health

The study of longitudinal data is vital in terms of accurately observing changes in responses of interest for individuals, communities, and larger populations over time. Linear mixed effects models (for continuous responses observed over time) and generalized linear mixed effects models and generalized estimating equations (for more general responses such as binary or count data observed over time) are the most popular techniques used for analyzing longitudinal data from health studies, though, as with all modeling techniques, these approaches have limitations, partly due to their underlying assumptions. In this review paper, we will discuss some advances, including curve-based techniques, which make modeling longitudinal data more flexible. Three examples will be presented from the health literature utilizing these more flexible procedures, with the goal of demonstrating that some otherwise difficult questions can be reasonably answered when analyzing complex longitudinal data in population health studies.